Menù principale
B020150 - GENERAL PATHOLOGY
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Sustainable Development Goals 2030
Academic Year 2023-24
Coorte 2022 - 3-years First Cycle Degree (DM 270/04) in DIETISTIC
Course year
Second year - First Semester
Belonging Department
Biomedical, Experimental and Clinical Sciences "Mario Serio"
Modulo di sola Frequenza of
Scientific Area
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY
Credits
2
Teaching Hours
24
Teaching Term
25/09/2023 ⇒ 31/01/2024
Attendance required
No
Type of Evaluation
Giudizio Finale
Course Content
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Course program
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Lectureship
Teaching Language
Inglese
Course Content
Definition of disease
Etiology and Pathogenesis
Cellular Pathology
Inflammation and Healing
Systemic Effects of Inflammation
Immunology and Immunopathology
Pathology of Growth and Differentiation
Oncology
Pathophysiology of Lipid disorders and metabolic diseases
(hyperuricemia, gout etc.)
Etiology and Pathogenesis
Cellular Pathology
Inflammation and Healing
Systemic Effects of Inflammation
Immunology and Immunopathology
Pathology of Growth and Differentiation
Oncology
Pathophysiology of Lipid disorders and metabolic diseases
(hyperuricemia, gout etc.)
Suggested readings (Search our library's catalogue)
G.M. Pontieri – Patologia generale fisiopatologia generale- Piccin
2012
2012
Learning Objectives
The course aims to provide knowledge of ethio-pathogenetic mechanisms of diseases within the fundamental areas of general pathology such as cell pathology, inflammation, immune responses and oncology.
Such knowledge is the basic prerequisite for understanding how dietary principles can be a cause of disease but also a means to prevent the disease itself
Such knowledge is the basic prerequisite for understanding how dietary principles can be a cause of disease but also a means to prevent the disease itself
Prerequisites
Knowledge of biochemistry, anatomy, Physiology and genetics
Preparatory courses:
Biomedical Science 1
Biomedical Science 2
Preparatory courses:
Biomedical Science 1
Biomedical Science 2
Teaching Methods
Lectures and seminars.
Pdf or Power Point presentations will be utilised during the lessons and a copy of it will be available for the students.
The slides will be also available on the Moodle platform
Pdf or Power Point presentations will be utilised during the lessons and a copy of it will be available for the students.
The slides will be also available on the Moodle platform
Further information
Office hours:
daily by appointment by phone or by email: daniela.monti@unifi.it
daily by appointment by phone or by email: daniela.monti@unifi.it
Type of Assessment
The final test will consist in an oral or written exam aimed at verifying the
students' knowledge on the course topics. The oral examination consists
of 2-3 questions about the topics of the program and on the material available in Moodle platform. The final grade is made by
evaluating the clarity of explanation, the ability to link and communication skills of the student. The written exam consists in a
computer multiple-choice test.
students' knowledge on the course topics. The oral examination consists
of 2-3 questions about the topics of the program and on the material available in Moodle platform. The final grade is made by
evaluating the clarity of explanation, the ability to link and communication skills of the student. The written exam consists in a
computer multiple-choice test.
Course program
Concept of etiology and pathogenesis. Introduction to general pathology: Homeostasis concept. Concept of disease as an alteration of functions performed at the cellular level and / or integrated systems. Major damaging stimuli and their response from cells: from elementary biochemical lesion to its metabolic and phenotypic effects.
Cellular pathology: Responses to damage. Free radical damage. Hypoxic damage and infarction. Adaptation to hypoxia and heat-shock response. Hyperlipidemia and steatosis. Different types of Cell death (necrosis, gangrene, apoptosis etc.). Cellular adaptation: hypertrophy, hyperplasia, atrophy, metaplasia.
Inflammation and Healing. Acute inflammation: Acute inflammation: vascular phenomena, plasma and tissue mediators, chemotaxis, physiology and biochemistry of phagocytosis, defects of phagocytosis, exudate and its chemical characteristics: erythematous, serous, fibrinous, purulent, hemorrhagic inflammation. Chronic inflammation: chronic nonspecific inflammation and granulomatous inflammation. Healing process: regenerative and reparative processes, local and general factors affecting the process of healing, healing of specialized tissues (bone, muscle, nerve), complications of the healing (fibrosis). The systemic effects of inflammation: acute phase proteins and amyloidosis, erythrocyte sedimentation rate, leukocytosis, and fever. Physiological aspects of temperature control, exogenous and endogenous pyrogens, types of fever, metabolic changes of the feverish patient.
Immunobiology and immunopathology. Characteristics and determinants of innate and acquired immunity, definition of antigen, Receptor of B and T lymphocytes, The major histocompatibility complex molecules (MHC class I and II), cellular and molecular basis of the immune response, effector mechanisms of the immune response, primary and secondary response to antigens, active and passive prophylaxis ((vaccination and anti-serum injection), Types of hypersensitivity reactions (I, II, III and IV type)
Oncology. Concept of tumor: tumor as genetic disease of somatic cells. Oncogenes, onco-suppressor genes and caretaker genes. The malignant neoplastic phenotype: angiogenesis, infiltration, metastasis, chemotherapy. Classification of tumors and tumor markers. Histopathological Aspects of Major Tumors, Leukemia and Lymphomas
Pathophysiology of Lipids and metabolic disease. Examples of Pathophysiology: hyperuricemia and gout. Creutzfeldt-Jakob disease and prion diseases in amyloidosis
Cellular pathology: Responses to damage. Free radical damage. Hypoxic damage and infarction. Adaptation to hypoxia and heat-shock response. Hyperlipidemia and steatosis. Different types of Cell death (necrosis, gangrene, apoptosis etc.). Cellular adaptation: hypertrophy, hyperplasia, atrophy, metaplasia.
Inflammation and Healing. Acute inflammation: Acute inflammation: vascular phenomena, plasma and tissue mediators, chemotaxis, physiology and biochemistry of phagocytosis, defects of phagocytosis, exudate and its chemical characteristics: erythematous, serous, fibrinous, purulent, hemorrhagic inflammation. Chronic inflammation: chronic nonspecific inflammation and granulomatous inflammation. Healing process: regenerative and reparative processes, local and general factors affecting the process of healing, healing of specialized tissues (bone, muscle, nerve), complications of the healing (fibrosis). The systemic effects of inflammation: acute phase proteins and amyloidosis, erythrocyte sedimentation rate, leukocytosis, and fever. Physiological aspects of temperature control, exogenous and endogenous pyrogens, types of fever, metabolic changes of the feverish patient.
Immunobiology and immunopathology. Characteristics and determinants of innate and acquired immunity, definition of antigen, Receptor of B and T lymphocytes, The major histocompatibility complex molecules (MHC class I and II), cellular and molecular basis of the immune response, effector mechanisms of the immune response, primary and secondary response to antigens, active and passive prophylaxis ((vaccination and anti-serum injection), Types of hypersensitivity reactions (I, II, III and IV type)
Oncology. Concept of tumor: tumor as genetic disease of somatic cells. Oncogenes, onco-suppressor genes and caretaker genes. The malignant neoplastic phenotype: angiogenesis, infiltration, metastasis, chemotherapy. Classification of tumors and tumor markers. Histopathological Aspects of Major Tumors, Leukemia and Lymphomas
Pathophysiology of Lipids and metabolic disease. Examples of Pathophysiology: hyperuricemia and gout. Creutzfeldt-Jakob disease and prion diseases in amyloidosis
Sustainable Development Goals 2030
This teaching contributes to the achievement of the ONU objectives of the 2030 Agenda for Sustainable Development