Menù principale
B016932 - BIOORGANIC CHEMISTRY
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Type of Assessment
Course program
Academic Year 2019-20
Course year
Third year - First Semester
Belonging Department
Experimantal and Clinical Medicine
Course Type
Single education field course
Scientific Area
CHIM/06 - ORGANIC CHEMISTRY
Credits
6
Teaching Hours
48
Teaching Term
30/09/2019 ⇒ 20/12/2019
Attendance required
No
Type of Evaluation
Final Grade
Course Content
show
Course program
show
Lectureship
Teaching Language
Italian
Course Content
Using the Central dogma of molecular biology, the different classes of biomolecules will be analized, using organic chemistry to understand the synthesis (bio- and laboratory synthesis) and the function of the molecules that constitute living organisms.
Suggested readings (Search our library's catalogue)
A list of suggested textbooks will be given at the beginning of the course
Learning Objectives
At the end of the course, the students should be familiar with the main classes of biomolecules and the monomers from which they are formed, they should understand their interactions with other molecules and, consequently, their function and possible manipulation for research and therapeutic purposes
Prerequisites
basic knowledge of organic chemistry
Teaching Methods
thaught lesson, interactive teaching and excercises
Type of Assessment
oral exam
Course program
Diversification and selection as basis for evolution. Combinatorial assembly generates diversity in nature. The energetics of reactivity and the non-bonding interactions among molecules. Nucleic acids. DNA: its structure, (deoxy)mnucleotides and their characteristics, chemical synthesis of DNA, examples of bioorganic chemistry of DNA. Alkylating agents as anticancer drugs and their interaction with DNA. RNA:difference with DNA (structure and stability), synthesis of RNA, RNA as catalyst, sliceosome vs ribozymes. Translation of RNA into proteins. Amino acids and proteins, chemical properties and structures. What are receptors, receptor-ligand interaction. Catalytic function of proteins. Enyzmes and their application in organic synthesis (examples: lipases, esterases, oxidoreductases). Coenzymes. Introduction to pharmacology. Kinases and GPCRs and their role as targets in bioorganic and medicinal chemistry. Chemical synthesis of peptides and proteins. Modifications and therapeutic applications of peptides and proteins. Examples of other applications in biotechnology. Introduction to other classes of biomolecules (glycans, polyketides and terpenes). Analysis of articles from the recent scientific literature related to the topics discussed during the course.