Menù principale
B021121 - BIOCHEMISTRY III
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Academic Year 2017-18
Coorte 2016 - 6-years Single Cycle Degree in MEDICINA E CHIRURGIA
Course year
Second year - First Semester
Belonging Department
Experimantal and Clinical Medicine
Modulo di sola Frequenza of
Scientific Area
BIO/10 - BIOCHEMISTRY
Credits
5
Teaching Hours
60
Teaching Term
25/09/2017 ⇒ 30/04/2019
Attendance required
Yes
Type of Evaluation
Giudizio Finale
Course Content
show
Course program
show
Lectureship
- Part A CHIARUGI PAOLA
- Part A CIRRI PAOLO
- Part B BERTI ANDREA
- Part B DEGL'INNOCENTI DONATELLA
- Part B TADDEI NICCOLO'
Teaching Language - Part A
Italian
Teaching Language - Part B
Italian
Course Content - Part A
Hormones, Their classification, their physiological function and the mechanisms of action. The hypothalamic-pituitary system. The glycoprotein hormones. Insulin. Glucagon. The steroid hormones. Thyroid hormones. Homeostasis of calcium. The eicosanoids.
The liver. The blood biochemistry. The nervous tissue. The vision. The muscle and muscle contraction. Adipose tissue.
The liver. The blood biochemistry. The nervous tissue. The vision. The muscle and muscle contraction. Adipose tissue.
Course Content - Part B
Hormones: classification, structure, biosynthesis, physiological function and mechanisms of action. The hypothalamic-pituitary system. The glycoprotein hormones. Insulin. Glucagon. Steroid hormones. Thyroid hormones. Homeostasis of calcium. Eicosanoids.
Oxygen reactive species and oxydative stress.
Human systemic biochemistry. The liver. Plasma and blood biochemistry. The nervous tissue. The vision. The muscle and muscle contraction. Adipose tissue.
Oxygen reactive species and oxydative stress.
Human systemic biochemistry. The liver. Plasma and blood biochemistry. The nervous tissue. The vision. The muscle and muscle contraction. Adipose tissue.
Suggested readings - Part A (Search our library's catalogue)
Silipandi e Tettamanti, Biochimica Medica, Piccin
Caldarera, Biochimica Sistematica Umana, CLUEB
Caldarera, Biochimica Sistematica Umana, CLUEB
Suggested readings - Part B (Search our library's catalogue)
Silipandi e Tettamanti, Biochimica Medica, Piccin
Caldarera, Biochimica Sistematica Umana, CLUEB
Caldarera, Biochimica Sistematica Umana, CLUEB
Learning Objectives - Part A
Knowledge and understanding: The form of Biochemistry-III has as its main aim is to acquire students with knowledge of Biochemistry of the endocrine system and systematic human biochemistry.
Applying knowledge and understanding: The knowledge gained in Biochemistry III module are preparatory to the Molecular Biology II modules, and will allow the student to understand the hormonal biochemistry, the basis of the intercellular and intracellular communication, and contextualization of metabolism in various organs and the inter-organ relationship. They will also be fundamental to correlate the knowledge of the CI of Biochemistry with the courses of the following years.
Applying knowledge and understanding: The knowledge gained in Biochemistry III module are preparatory to the Molecular Biology II modules, and will allow the student to understand the hormonal biochemistry, the basis of the intercellular and intracellular communication, and contextualization of metabolism in various organs and the inter-organ relationship. They will also be fundamental to correlate the knowledge of the CI of Biochemistry with the courses of the following years.
Learning Objectives - Part B
Knowledge and understanding: The form of Biochemistry-III has as its main aim is to acquire students with knowledge of Biochemistry of the endocrine system and systematic human biochemistry.
Applying knowledge and understanding: The knowledge gained in Biochemistry III module are preparatory to the Molecular Biology II modules, and will allow the student to understand the hormonal biochemistry, the basis of the intercellular and intracellular communication, and contextualization of metabolism in various organs and the inter-organ relationship. They will also be fundamental to correlate the knowledge of the CI of Biochemistry with the courses of the following years.
Applying knowledge and understanding: The knowledge gained in Biochemistry III module are preparatory to the Molecular Biology II modules, and will allow the student to understand the hormonal biochemistry, the basis of the intercellular and intracellular communication, and contextualization of metabolism in various organs and the inter-organ relationship. They will also be fundamental to correlate the knowledge of the CI of Biochemistry with the courses of the following years.
Prerequisites - Part A
Prerequisites approved by CDL
Prerequisites - Part B
Prerequisites approved by CDL
Teaching Methods - Part A
Lectures
Teaching Methods - Part B
Lectures
Further information - Part A
E-learning:http://didonline.med.unifi.it/index.php
Further information - Part B
E-learning:http://didonline.med.unifi.it/index.php
Type of Assessment - Part A
Oral examination
Type of Assessment - Part B
Oral examination
Course program - Part A
Hormone Biochemistry: Hormones, their classification, their physiological function and the mechanisms of their action. Endocrine hormones, paracrine and autocrine hormones.
The hierarchical organization of the endocrine system: the hypothalamic-pituitary system, releasing factors, factors inhibiting the release, GH, PRL, placental lactogen.
Glycoprotein hormones, TSH, FSH, LH, HCG. Insulin: synthesis, maturation and release.
The types of receptor, their superfamilies classification, desensitization and down-regulation.
Glucagon and its receptors.
Catecholamines, biosynthesis, degradation, and their receptors.
Biosynthesis of steroid hormones and regulation. The mineral-corticoids. Glucocorticoids. The anti-inflammatory hormones. Sex steroids. Progestinic hormones.
The thyroid hormones T3 and T4. Biosynthesis and role.
Calcium homeostasis: parathyroid hormone, calcitonin and vitamin D.
Hormones that are derived from arachidonic acid, the eicosanoids. NSAD (aspirin, ibuprofen, COX1-2).
The receptors of steroid and thyroid hormones. HSP chaperones
Systematic human biochemistry:
Metabolism of some of the major organs and their correlation and integration of function.
The metabolic specialization of liver tissue, particularly the liver role in regulating blood sugar, in lipid and ketone bodies management, lipoprotein biosynthesis, role of bile pigments (notes on the various types jaundice), the mechanisms of xenobiotics detoxification, metabolism of ethanol and its toxicity .
Biochemistry of blood. Plasma composition. Lipoproteins. Erythrocyte: biosynthesis and role of 2,3-bisphosphoglyceric acid. Fetal hemoglobin and pathological hemoglobins. Metabolism of lymphocytes and granulocytes. Metabolism of platelets and their activation. Coagulation and fibrinolysis.
The metabolic specialization of the nerve tissue. Ion channel proteins. Neurotransmitters and neuromodulators. The fatty acids of the nervous tissue. Biochemical mechanism of vision.
The metabolic specialization of skeletal and cardiac muscle tissue. The smooth muscle tissue. Actin, myosin, tropomyosin. Hormones that regulate the contraction and its efficiency.
The function of adipose tissue, white and brown.. Tissue distribution and plasticity of the two tissues (browning and whitening) and its regulation.
The hierarchical organization of the endocrine system: the hypothalamic-pituitary system, releasing factors, factors inhibiting the release, GH, PRL, placental lactogen.
Glycoprotein hormones, TSH, FSH, LH, HCG. Insulin: synthesis, maturation and release.
The types of receptor, their superfamilies classification, desensitization and down-regulation.
Glucagon and its receptors.
Catecholamines, biosynthesis, degradation, and their receptors.
Biosynthesis of steroid hormones and regulation. The mineral-corticoids. Glucocorticoids. The anti-inflammatory hormones. Sex steroids. Progestinic hormones.
The thyroid hormones T3 and T4. Biosynthesis and role.
Calcium homeostasis: parathyroid hormone, calcitonin and vitamin D.
Hormones that are derived from arachidonic acid, the eicosanoids. NSAD (aspirin, ibuprofen, COX1-2).
The receptors of steroid and thyroid hormones. HSP chaperones
Systematic human biochemistry:
Metabolism of some of the major organs and their correlation and integration of function.
The metabolic specialization of liver tissue, particularly the liver role in regulating blood sugar, in lipid and ketone bodies management, lipoprotein biosynthesis, role of bile pigments (notes on the various types jaundice), the mechanisms of xenobiotics detoxification, metabolism of ethanol and its toxicity .
Biochemistry of blood. Plasma composition. Lipoproteins. Erythrocyte: biosynthesis and role of 2,3-bisphosphoglyceric acid. Fetal hemoglobin and pathological hemoglobins. Metabolism of lymphocytes and granulocytes. Metabolism of platelets and their activation. Coagulation and fibrinolysis.
The metabolic specialization of the nerve tissue. Ion channel proteins. Neurotransmitters and neuromodulators. The fatty acids of the nervous tissue. Biochemical mechanism of vision.
The metabolic specialization of skeletal and cardiac muscle tissue. The smooth muscle tissue. Actin, myosin, tropomyosin. Hormones that regulate the contraction and its efficiency.
The function of adipose tissue, white and brown.. Tissue distribution and plasticity of the two tissues (browning and whitening) and its regulation.
Course program - Part B
Hormone Biochemistry: Hormones, their classification, their physiological function and the mechanisms of their action. Endocrine hormones, paracrine and autocrine hormones.
The hierarchical organization of the endocrine system: the hypothalamic-pituitary system, releasing factors, factors inhibiting the release, GH, PRL, placental lactogen.
Glycoprotein hormones, TSH, FSH, LH, HCG. Insulin: synthesis, maturation and release. Glucagon.
Catecholamines, biosynthesis, degradation, and function.
Biosynthesis of steroid hormones and regulation. The mineral-corticoids. Glucocorticoids. The anti-inflammatory hormones. Sex steroids. Progestinic hormones.
The thyroid hormones T3 and T4. Biosynthesis and role.
Calcium homeostasis: parathyroid hormone, calcitonin and vitamin D.
Hormones that are derived from arachidonic acid, the eicosanoids. NSAD (aspirin, ibuprofen, COX1-2).
Oxygen and nitrogen reactive species: chemical structure and production mecahnisms. Cell damage by ROS and RNOS. Defence mechanisms against ROS: enzymatic systems (Superoxyde dismutase, catalase and glutathione peroxydase); scavenegers. Redox balance. Oxydative stress.
Systematic human biochemistry:
Metabolism of some of the major organs and their correlation and integration of function.
The metabolic specialization of liver tissue, particularly the liver role in regulating blood sugar, in lipid and ketone bodies management, lipoprotein biosynthesis, role of bile pigments (notes on the various types jaundice), the mechanisms of xenobiotics detoxification, metabolism of ethanol and its toxicity .
Biochemistry of blood. Plasma composition. Plasmaproteins. Erythrocyte: biosynthesis and role of 2,3-bisphosphoglyceric acid. Fetal hemoglobin and pathological hemoglobins. Metabolism of lymphocytes and granulocytes. Metabolism of platelets and their activation. Coagulation and fibrinolysis.
The metabolic specialization of the nerve tissue. Ion channel proteins. Neurotransmitters and neuromodulators. The fatty acids of the nervous tissue. The metabolic specialization of skeletal and cardiac muscle tissue. The smooth muscle tissue. Actin, myosin, tropomyosin and troponines. Hormones that regulate the contraction and its efficiency.
The function of adipose tissue, white and brown. Tissue distribution and plasticity of the two tissues (browning and whitening) and its regulation.
The hierarchical organization of the endocrine system: the hypothalamic-pituitary system, releasing factors, factors inhibiting the release, GH, PRL, placental lactogen.
Glycoprotein hormones, TSH, FSH, LH, HCG. Insulin: synthesis, maturation and release. Glucagon.
Catecholamines, biosynthesis, degradation, and function.
Biosynthesis of steroid hormones and regulation. The mineral-corticoids. Glucocorticoids. The anti-inflammatory hormones. Sex steroids. Progestinic hormones.
The thyroid hormones T3 and T4. Biosynthesis and role.
Calcium homeostasis: parathyroid hormone, calcitonin and vitamin D.
Hormones that are derived from arachidonic acid, the eicosanoids. NSAD (aspirin, ibuprofen, COX1-2).
Oxygen and nitrogen reactive species: chemical structure and production mecahnisms. Cell damage by ROS and RNOS. Defence mechanisms against ROS: enzymatic systems (Superoxyde dismutase, catalase and glutathione peroxydase); scavenegers. Redox balance. Oxydative stress.
Systematic human biochemistry:
Metabolism of some of the major organs and their correlation and integration of function.
The metabolic specialization of liver tissue, particularly the liver role in regulating blood sugar, in lipid and ketone bodies management, lipoprotein biosynthesis, role of bile pigments (notes on the various types jaundice), the mechanisms of xenobiotics detoxification, metabolism of ethanol and its toxicity .
Biochemistry of blood. Plasma composition. Plasmaproteins. Erythrocyte: biosynthesis and role of 2,3-bisphosphoglyceric acid. Fetal hemoglobin and pathological hemoglobins. Metabolism of lymphocytes and granulocytes. Metabolism of platelets and their activation. Coagulation and fibrinolysis.
The metabolic specialization of the nerve tissue. Ion channel proteins. Neurotransmitters and neuromodulators. The fatty acids of the nervous tissue. The metabolic specialization of skeletal and cardiac muscle tissue. The smooth muscle tissue. Actin, myosin, tropomyosin and troponines. Hormones that regulate the contraction and its efficiency.
The function of adipose tissue, white and brown. Tissue distribution and plasticity of the two tissues (browning and whitening) and its regulation.