Menù principale
B014254 - PHARMACOLOGY II
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Academic Year 2017-18
Coorte 2014 - 6-years Single Cycle Degree in Medicine and Surgery
Course year
Fourth year - Second Semester
Belonging Department
Experimantal and Clinical Medicine
Modulo di sola Frequenza of
Scientific Area
BIO/14 - PHARMACOLOGY
Credits
7
Teaching Hours
84
Teaching Term
26/02/2018 ⇒ 30/04/2019
Attendance required
Yes
Type of Evaluation
Giudizio Finale
Course Content
show
Course program
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Lectureship
- Part A CORRADETTI RENATO
- Part A MANNAIONI GUIDO
- Part A MASINI EMANUELA
- Part A MAZZEI TERESITA
- Part A MUGELLI ALESSANDRO
- Part B CHIARUGI ALBERTO
- Part B GEPPETTI PIERANGELO
- Part B NOVELLI ANDREA
- Part B PELLEGRINI-GIAMPIETRO DOMENICO EDOARDO
Teaching Language - Part A
Italian
Teaching Language - Part B
English
Course Content - Part A
Major objective of the course is to provide the pharmacological basis of therapeutics, including toxicology and drug addiction. Medicines representative of therapeutic classes are illustrated for their chemical nature, pharmacological action(s), mechanism(s) of action, therapeutic indication(s), pharmacokinetic characteristics, efficacy, safety, adverse reactions, toxicity, contraindications, drug interactions, doses and administration route.
Course Content - Part B
Special pharmacology: Cardiovascular (IV year- I semester), Antibacterial and antitumoral chemiotherapy (IV year- I semester) - Neurophyopharmacology and Toxicology (IV year- II semester) - Clinical pharmacology (IV year- II semester)
Suggested readings - Part A (Search our library's catalogue)
BIBLIOGRAFIA
GOODMAN & GILMAN's. The pharmacological basis of therapy; 13th ed, 2017
ROSSI F, CUOMO V, RICCARDI C. -Farmacologia. Principi di base e applicazioni Terapeutiche, Edizioni Minerva Medica 2017
KATZUNG & TREVOR A.J. -Basic and Clinical Pharmacology, 14th Ed , Lange , 2017
GOODMAN & GILMAN's. The pharmacological basis of therapy; 13th ed, 2017
ROSSI F, CUOMO V, RICCARDI C. -Farmacologia. Principi di base e applicazioni Terapeutiche, Edizioni Minerva Medica 2017
KATZUNG & TREVOR A.J. -Basic and Clinical Pharmacology, 14th Ed , Lange , 2017
Suggested readings - Part B (Search our library's catalogue)
BIBLIOGRAFIA
ROSSI F, CUOMO V, RICCARDI C. -Farmacologia. Principi di base e applicazioni Terapeutiche, Edizioni Minerva Medica 2011
L. ANNUNZIATO - G. DI RENZO -Trattato di Farmacologia, Edizioni Idelson-Gnocchi 2010
GOODMAN L.S. & GILMAN A.: Le basi farmacologiche della terapia XII ed. Italiana, Zanichelli, 2012
KATZUNG B.G., PREZIOSI P, MASTERS S.B, TREVOR A.J. -Farmacologia Generale e Clinica, IX edizione italiana , Piccin, 2014
L. GOVONI Farmacologia Casa Editrice Ambrosiana. 2014
ROSSI F, CUOMO V, RICCARDI C. -Farmacologia. Principi di base e applicazioni Terapeutiche, Edizioni Minerva Medica 2011
L. ANNUNZIATO - G. DI RENZO -Trattato di Farmacologia, Edizioni Idelson-Gnocchi 2010
GOODMAN L.S. & GILMAN A.: Le basi farmacologiche della terapia XII ed. Italiana, Zanichelli, 2012
KATZUNG B.G., PREZIOSI P, MASTERS S.B, TREVOR A.J. -Farmacologia Generale e Clinica, IX edizione italiana , Piccin, 2014
L. GOVONI Farmacologia Casa Editrice Ambrosiana. 2014
Learning Objectives - Part A
Formative assessment
Knowledge and understanding: pharmacological bases for the treatment of human diseases including the effects of abuse and toxic substances.
Ability to apply knowledge and understanding: representative drugs of the various therapeutic classes (chemical nature, pharmacological actions, mechanism of action, therapeutic indications, pharmacokinetic, efficacy, safety, adverse effects, toxicity, contraindications, interactions with other drugs, doses and routes of administration). Check the information on the web site: http://didonline.med.unifi.it/content.php?cid=81
Knowledge and understanding: pharmacological bases for the treatment of human diseases including the effects of abuse and toxic substances.
Ability to apply knowledge and understanding: representative drugs of the various therapeutic classes (chemical nature, pharmacological actions, mechanism of action, therapeutic indications, pharmacokinetic, efficacy, safety, adverse effects, toxicity, contraindications, interactions with other drugs, doses and routes of administration). Check the information on the web site: http://didonline.med.unifi.it/content.php?cid=81
Learning Objectives - Part B
Knowledge and understanding: Pharmacological bases for the therapy of human pathologies including the effects of drugs of abuse and toxic substances.
Ability to apply knowledge and understanding: Representative drugs of the various therapeutic classes (chemical nature, pharmacological actions, mechanism of action, therapeutic indications, pharmacokinetic features, efficacy, safety, adverse effects, toxicity, contraindications, interactions with other drugs, doses and routes of administration). See information on the web site: http://didonline.med.unifi.it/content.php?cid=81
Ability to apply knowledge and understanding: Representative drugs of the various therapeutic classes (chemical nature, pharmacological actions, mechanism of action, therapeutic indications, pharmacokinetic features, efficacy, safety, adverse effects, toxicity, contraindications, interactions with other drugs, doses and routes of administration). See information on the web site: http://didonline.med.unifi.it/content.php?cid=81
Prerequisites - Part A
Successful overcoming of the examination during the course
Prerequisites - Part B
Knowledge of anatomy, physiology and biochemistry
Teaching Methods - Part A
Frontal lectures
Teaching Methods - Part B
The course takes place in the first and second semesters of the IV year by means of frontal oral classes
Further information - Part A
The course takes place in the first and second semesters of the IV year
Type of Assessment - Part A
Oral Profit Exam. The final assessment of the teaching takes into account the results achieved in the individual teaching units
Type of Assessment - Part B
Oral Profit Exam. The assessment takes into account the costant commitment of the student in all the phases of the formative process. In particular, the following are verified: the knowledge and learning of the basic notions delivered during the frontal lessons and through the teaching material and the devolpemnt of critical sense on the topics of the subject. The oral exam or the written test are carried out in fornt of the teacher in public form exclusively on the dates indicated in the exam calendar. The final assessment of the teaching takes into account the results achieved in the individual teaching units
Course program - Part A
SPECIAL PHARMACOLOGY
- ANTIBACTERIAL AND ANTITUMORAL CHEMIOTHERAPY (IV YEAR- I SEMESTER)
1. Introduction and principles of pharmacokinetics and pharmacodynamics in chemotherapy. Classify antimicrobials based on bacteriostatic or bactericidal activity, the structural membership group (beta-lactams, aminoglycosides, etc.), the mechanism of action, and the prevailing action spectrum (gram + or -).
2. Drug Resistance, Antimicrobial Drug Associations, Antibiotic Prophylaxis.
3. Complications of antibiotic therapy. Choice of antimicrobial drugs.
4. Sulfamidics, trimethoprim and cotrimoxazole.
Penicillins, cephalosporins, other betalattamines and betalattamasic inhibitors.
6. Other antibiotics that affect the cell wall.
7. Tetracycline, chloramphenicol, and new antimicrobial chemotherapists.
8. Lincosamine.
9. Aminoglucoside.
10. Glycopeptide.
11. Glucosidic macrolides, Ketolidi.
12. Chinolones and urinary antiseptics, fluoroquinolones.
13. Antituberculosis and antileprosis.
14. Drugs for mycotic infections.
15. Antivirals: medicines for respiratory viruses and herpes viruses. Drugs active against hepatitis viruses.
16. Drugs active against HIV.
17. Medicaments for the treatment of nematode, tremor and cystode infections.
18. Classify antiprotozoal drugs in relation to therapeutic indications and use patterns: trypanosomiasis, leishmaniosis, malaria. Pharmacological prevention of malaria.
19. Principles of antineoplastic chemotherapy.
20. Alkylating agents, antimetabolites, topoisomerase inhibitors, mitotic mitochondrial inhibitors, signal transduction inhibitors, cytotoxic antibodies.
21. Anti-Hormonal Drugs.
SPECIAL PHARMACOLOGY
- CARDIOVASCULAR (IV YEAR- II SEMESTER)
1. Cardiovascular risk factors.
2. Hypertension Drugs - Throat, Thyroid and Potassium Thyroid Diuretics, Carbon Anhydrase Inhibitors and Osmotic Diuretics.
3. Beta Blockers Drugs.
4. Other systolic agents -Ivabradine.
5. Calcium channel blockers.
6. Renal Angiotensin Aldosterone Enzyme Drugs.
7. Statins and Anti- Drugs for Treating Dyslipidemia.
8. Diabetes Drugs: Oral hypoglycemic, insulin preparations.
9. Other cardiovascular risk factors.
10. Drugs of ischemic heart disease.
11 Nitrates., antianginal - ranolazine.
12. Drugs for heart failure.
13. Inotropi.
14. Digitalis.
15. Classes I-IV anti-arrhythmic drugs of and others.
16. Coagulation modifiers: platelet aggregation inhibitors, thrombolytic agents, medicines used to treat hemorrhage.
SPECIAL PHARMACOLOGY
- NEUROPHYOPHARMACOLOGY AND TOXICOLOGY (IV YEAR-II SEMESTER)
1. Dopaminergic and Anticholinergic in Parkinson's disease. Differentiate the pharmacotherapeutic characteristics of the drugs indicated in Parkinson's disease and Parkinsonism.
2. Antipsychotics.
3. Dopaminergic agents in neuroendocrinological and antidopaminergic diseases such as antiemetics.
4. Antiepileptics.
5. Antidepressants and anti-inflammatory drugs: Compare the different classes of antidepressants for action mechanisms, therapeutic indications and unwanted effects.
6. Drugs for neuropathic pain.
7. Anxiolytics: Describe the pharmacological actions and the indications of benzodiazepines and other anxiolytic agents in relation to the mechanisms of action and pharmacokinetics.
8. Hypnotics: Describe the indications of benzodiazepines and other hypnotics that correlate with the mechanisms of action and pharmacokinetics.
9. Opioid analgesics: agonists, partial agonists and antagonists - Describe the pharmacological (therapeutic and toxicological) characteristics and the methods of use of opioid analgesics: agonists, partial agonists and antagonists.
10. Principles of Pain Treatment.
11. Drugs used to treat migraine.
12. General anesthetics.
13. Drugs for Alzheimer's Therapy.
14. Drugs in cerebral ischemia.
15. Experimental methods for the control of drug and xenobiotic toxicity.
16. Dose-effect and Time-Effect Report of Toxic Diseases by Drugs and Xenobiotics.
17. Benzodiazepine Dependence.
18. Acute alcoholism and alcohol use disorder.
19. Opioid use disorder.
20. Psychostimulants and hallucinogens, Club-Drugs.
21. CO and cyanide poisoning.
22. Pesticides.
23. Mushroom poisoning.
24. Antidotes and other anti-inflammatory measures.
25. Adverse Drug Reactions.
26. Drug allergy.
CLINICAL PHARMACOLOGY
1. Prescription drugs, controlled drug tables.
2. Pharmacovigilance.
3. Evidence-Based Medicine and Clinical Trials of Drugs
4. Pharmacoepidemiology, PharmacoEconomics.
5. Complementary or Alternative Medicines, Professional Responsibilities, and Appropriate Behavior by the Medical Practitioner
6. Principles on which to base the effects of major complementary or alternative therapies (Western Phytotherapy, Acupuncture, Chinese Phytotherapy,
7. The role of phytotherapy in the light of scientific evidence and the main traditional branches of common use. Possible side effects and risks of drug interaction between phytotherapy and medication.
- ANTIBACTERIAL AND ANTITUMORAL CHEMIOTHERAPY (IV YEAR- I SEMESTER)
1. Introduction and principles of pharmacokinetics and pharmacodynamics in chemotherapy. Classify antimicrobials based on bacteriostatic or bactericidal activity, the structural membership group (beta-lactams, aminoglycosides, etc.), the mechanism of action, and the prevailing action spectrum (gram + or -).
2. Drug Resistance, Antimicrobial Drug Associations, Antibiotic Prophylaxis.
3. Complications of antibiotic therapy. Choice of antimicrobial drugs.
4. Sulfamidics, trimethoprim and cotrimoxazole.
Penicillins, cephalosporins, other betalattamines and betalattamasic inhibitors.
6. Other antibiotics that affect the cell wall.
7. Tetracycline, chloramphenicol, and new antimicrobial chemotherapists.
8. Lincosamine.
9. Aminoglucoside.
10. Glycopeptide.
11. Glucosidic macrolides, Ketolidi.
12. Chinolones and urinary antiseptics, fluoroquinolones.
13. Antituberculosis and antileprosis.
14. Drugs for mycotic infections.
15. Antivirals: medicines for respiratory viruses and herpes viruses. Drugs active against hepatitis viruses.
16. Drugs active against HIV.
17. Medicaments for the treatment of nematode, tremor and cystode infections.
18. Classify antiprotozoal drugs in relation to therapeutic indications and use patterns: trypanosomiasis, leishmaniosis, malaria. Pharmacological prevention of malaria.
19. Principles of antineoplastic chemotherapy.
20. Alkylating agents, antimetabolites, topoisomerase inhibitors, mitotic mitochondrial inhibitors, signal transduction inhibitors, cytotoxic antibodies.
21. Anti-Hormonal Drugs.
SPECIAL PHARMACOLOGY
- CARDIOVASCULAR (IV YEAR- II SEMESTER)
1. Cardiovascular risk factors.
2. Hypertension Drugs - Throat, Thyroid and Potassium Thyroid Diuretics, Carbon Anhydrase Inhibitors and Osmotic Diuretics.
3. Beta Blockers Drugs.
4. Other systolic agents -Ivabradine.
5. Calcium channel blockers.
6. Renal Angiotensin Aldosterone Enzyme Drugs.
7. Statins and Anti- Drugs for Treating Dyslipidemia.
8. Diabetes Drugs: Oral hypoglycemic, insulin preparations.
9. Other cardiovascular risk factors.
10. Drugs of ischemic heart disease.
11 Nitrates., antianginal - ranolazine.
12. Drugs for heart failure.
13. Inotropi.
14. Digitalis.
15. Classes I-IV anti-arrhythmic drugs of and others.
16. Coagulation modifiers: platelet aggregation inhibitors, thrombolytic agents, medicines used to treat hemorrhage.
SPECIAL PHARMACOLOGY
- NEUROPHYOPHARMACOLOGY AND TOXICOLOGY (IV YEAR-II SEMESTER)
1. Dopaminergic and Anticholinergic in Parkinson's disease. Differentiate the pharmacotherapeutic characteristics of the drugs indicated in Parkinson's disease and Parkinsonism.
2. Antipsychotics.
3. Dopaminergic agents in neuroendocrinological and antidopaminergic diseases such as antiemetics.
4. Antiepileptics.
5. Antidepressants and anti-inflammatory drugs: Compare the different classes of antidepressants for action mechanisms, therapeutic indications and unwanted effects.
6. Drugs for neuropathic pain.
7. Anxiolytics: Describe the pharmacological actions and the indications of benzodiazepines and other anxiolytic agents in relation to the mechanisms of action and pharmacokinetics.
8. Hypnotics: Describe the indications of benzodiazepines and other hypnotics that correlate with the mechanisms of action and pharmacokinetics.
9. Opioid analgesics: agonists, partial agonists and antagonists - Describe the pharmacological (therapeutic and toxicological) characteristics and the methods of use of opioid analgesics: agonists, partial agonists and antagonists.
10. Principles of Pain Treatment.
11. Drugs used to treat migraine.
12. General anesthetics.
13. Drugs for Alzheimer's Therapy.
14. Drugs in cerebral ischemia.
15. Experimental methods for the control of drug and xenobiotic toxicity.
16. Dose-effect and Time-Effect Report of Toxic Diseases by Drugs and Xenobiotics.
17. Benzodiazepine Dependence.
18. Acute alcoholism and alcohol use disorder.
19. Opioid use disorder.
20. Psychostimulants and hallucinogens, Club-Drugs.
21. CO and cyanide poisoning.
22. Pesticides.
23. Mushroom poisoning.
24. Antidotes and other anti-inflammatory measures.
25. Adverse Drug Reactions.
26. Drug allergy.
CLINICAL PHARMACOLOGY
1. Prescription drugs, controlled drug tables.
2. Pharmacovigilance.
3. Evidence-Based Medicine and Clinical Trials of Drugs
4. Pharmacoepidemiology, PharmacoEconomics.
5. Complementary or Alternative Medicines, Professional Responsibilities, and Appropriate Behavior by the Medical Practitioner
6. Principles on which to base the effects of major complementary or alternative therapies (Western Phytotherapy, Acupuncture, Chinese Phytotherapy,
7. The role of phytotherapy in the light of scientific evidence and the main traditional branches of common use. Possible side effects and risks of drug interaction between phytotherapy and medication.
Course program - Part B
SPECIAL PHARMACOLOGY - CARDIOVASCULAR (IV YEAR- I SEMESTER)
1. Cardiovascular risk factors.
2. Hypertension Drugs - Throat, Thyroid and Potassium Thyroid Diuretics, Carbon Anhydrase Inhibitors and Osmotic Diuretics.
3. Beta Blockers Drugs.
4. Other systolic agents -Ivabradine.
5. Calcium channel blockers.
6. Renal Angiotensin Aldosterone Enzyme Drugs.
7. Statins and Anti- Drugs for Treating Dyslipidemia.
8. Diabetes Drugs: Oral hypoglycemic, insulin preparations.
9. Other cardiovascular risk factors.
10. Drugs of ischemic heart disease.
11 Nitrates., antianginal - ranolazine.
12. Drugs for heart failure.
13. Inotropi.
14. Digitalis.
15. Classes I-IV anti-arrhythmic drugs of and others.
16. Coagulation modifiers: platelet aggregation inhibitors, thrombolytic agents, medicines used to treat hemorrhage.
SPECIAL PHARMACOLOGY - ANTIBACTERIAL AND ANTITUMORAL CHEMIOTHERAPY (IV YEAR- I SEMESTER)
1. Introduction and principles of pharmacokinetics and pharmacodynamics in chemotherapy. Classify antimicrobials based on bacteriostatic or bactericidal activity, the structural membership group (beta-lactams, aminoglycosides, etc.), the mechanism of action, and the prevailing action spectrum (Gram + or -).
2. Drug resistance, antimicrobial drug associations, antibiotic prophylaxis.
3. Complications of antibiotic therapy. Choice of antimicrobial drugs.
4. Sulfamidics, trimethoprim and cotrimoxazole.
Penicillins, cephalosporins, other betalattamines and betalattamasic inhibitors.
6. Other antibiotics that affect the cell wall.
7. Tetracycline, chloramphenicol, and new antimicrobial chemotherapists.
8. Lincosamine.
9. Aminoglucoside.
10. Glycopeptide.
11. Glucosidic macrolides, ketolides.
12. Chinolones and urinary antiseptics, fluoroquinolones.
13. Antituberculosis and antileprosis.
14. Drugs for mycotic infections.
15. Antivirals: medicines for respiratory viruses and herpes viruses. Drugs active against hepatitis viruses.
16. Drugs active against HIV.
17. Medicaments for the treatment of nematode, tremor and cystode infections.
18. Classify antiprotozoal drugs in relation to therapeutic indications and use patterns: trypanosomiasis, leishmaniosis, malaria. Pharmacological prevention of malaria.
19. Principles of antineoplastic chemotherapy.
20. Alkylating agents, antimetabolites, topoisomerase inhibitors, mitotic mitochondrial inhibitors, signal transduction inhibitors, cytotoxic antibodies.
21. Anti-hormonal drugs.
SPECIAL PHARMACOLOGY - NEUROPHYOPHARMACOLOGY AND TOXICOLOGY (IV YEAR-II SEMESTER)
1. Dopaminergic and anticholinergic in Parkinson's disease. Differentiate the pharmacotherapeutic characteristics of the drugs indicated in Parkinson's disease and Parkinsonism.
2. Antipsychotics.
3. Dopaminergic agents in neuroendocrinological and antidopaminergic diseases such as antiemetics.
4. Antiepileptics.
5. Antidepressants and anti-inflammatory drugs: Compare the different classes of antidepressants for action mechanisms, therapeutic indications and unwanted effects.
6. Drugs for neuropathic pain.
7. Anxiolytics: Describe the pharmacological actions and the indications of benzodiazepines and other anxiolytic agents in relation to the mechanisms of action and pharmacokinetics.
8. Hypnotics: Describe the indications of benzodiazepines and other hypnotics that correlate with the mechanisms of action and pharmacokinetics.
9. Opioid analgesics: agonists, partial agonists and antagonists - Describe the pharmacological (therapeutic and toxicological) characteristics and the methods of use of opioid analgesics: agonists, partial agonists and antagonists.
10. Principles of pain treatment.
11. Drugs used to treat migraine.
12. General anesthetics.
13. Drugs for Alzheimer's therapy.
14. Drugs in cerebral ischemia.
15. Experimental methods for the control of drug and xenobiotic toxicity.
16. Dose-effect and time-effect report of toxic diseases by drugs and xenobiotics.
17. Benzodiazepine dependence.
18. Acute alcoholism and alcohol use disorder.
19. Opioid use disorder.
20. Psychostimulants and hallucinogens, club-drugs.
21. CO and cyanide poisoning.
22. Pesticides.
23. Mushroom poisoning.
24. Antidotes and other anti-inflammatory measures.
25. Adverse drug reactions.
26. Drug allergy.
CLINICAL PHARMACOLOGY (IV YEAR – II SEMESTER)
1. Prescription drugs, controlled drug tables.
2. Pharmacovigilance.
3. Evidence-based medicine and clinical trials of drugs
4. Pharmacoepidemiology, pharmacoeconomics.
5. Complementary or alternative medicines, professional responsibilities, and appropriate behavior by the medical practitioner
6. Principles on which the effects of the major complementary or alternative therapies are based (Western phytotherapy, acupuncture, Chinese phytotherapy, ayurveda, homeopathy, osteopathy)
7. The role of phytotherapy in the light of scientific evidence and the main traditional branches of common use. Possible side effects and risks of drug interaction between phytotherapy and drug medication.
1. Cardiovascular risk factors.
2. Hypertension Drugs - Throat, Thyroid and Potassium Thyroid Diuretics, Carbon Anhydrase Inhibitors and Osmotic Diuretics.
3. Beta Blockers Drugs.
4. Other systolic agents -Ivabradine.
5. Calcium channel blockers.
6. Renal Angiotensin Aldosterone Enzyme Drugs.
7. Statins and Anti- Drugs for Treating Dyslipidemia.
8. Diabetes Drugs: Oral hypoglycemic, insulin preparations.
9. Other cardiovascular risk factors.
10. Drugs of ischemic heart disease.
11 Nitrates., antianginal - ranolazine.
12. Drugs for heart failure.
13. Inotropi.
14. Digitalis.
15. Classes I-IV anti-arrhythmic drugs of and others.
16. Coagulation modifiers: platelet aggregation inhibitors, thrombolytic agents, medicines used to treat hemorrhage.
SPECIAL PHARMACOLOGY - ANTIBACTERIAL AND ANTITUMORAL CHEMIOTHERAPY (IV YEAR- I SEMESTER)
1. Introduction and principles of pharmacokinetics and pharmacodynamics in chemotherapy. Classify antimicrobials based on bacteriostatic or bactericidal activity, the structural membership group (beta-lactams, aminoglycosides, etc.), the mechanism of action, and the prevailing action spectrum (Gram + or -).
2. Drug resistance, antimicrobial drug associations, antibiotic prophylaxis.
3. Complications of antibiotic therapy. Choice of antimicrobial drugs.
4. Sulfamidics, trimethoprim and cotrimoxazole.
Penicillins, cephalosporins, other betalattamines and betalattamasic inhibitors.
6. Other antibiotics that affect the cell wall.
7. Tetracycline, chloramphenicol, and new antimicrobial chemotherapists.
8. Lincosamine.
9. Aminoglucoside.
10. Glycopeptide.
11. Glucosidic macrolides, ketolides.
12. Chinolones and urinary antiseptics, fluoroquinolones.
13. Antituberculosis and antileprosis.
14. Drugs for mycotic infections.
15. Antivirals: medicines for respiratory viruses and herpes viruses. Drugs active against hepatitis viruses.
16. Drugs active against HIV.
17. Medicaments for the treatment of nematode, tremor and cystode infections.
18. Classify antiprotozoal drugs in relation to therapeutic indications and use patterns: trypanosomiasis, leishmaniosis, malaria. Pharmacological prevention of malaria.
19. Principles of antineoplastic chemotherapy.
20. Alkylating agents, antimetabolites, topoisomerase inhibitors, mitotic mitochondrial inhibitors, signal transduction inhibitors, cytotoxic antibodies.
21. Anti-hormonal drugs.
SPECIAL PHARMACOLOGY - NEUROPHYOPHARMACOLOGY AND TOXICOLOGY (IV YEAR-II SEMESTER)
1. Dopaminergic and anticholinergic in Parkinson's disease. Differentiate the pharmacotherapeutic characteristics of the drugs indicated in Parkinson's disease and Parkinsonism.
2. Antipsychotics.
3. Dopaminergic agents in neuroendocrinological and antidopaminergic diseases such as antiemetics.
4. Antiepileptics.
5. Antidepressants and anti-inflammatory drugs: Compare the different classes of antidepressants for action mechanisms, therapeutic indications and unwanted effects.
6. Drugs for neuropathic pain.
7. Anxiolytics: Describe the pharmacological actions and the indications of benzodiazepines and other anxiolytic agents in relation to the mechanisms of action and pharmacokinetics.
8. Hypnotics: Describe the indications of benzodiazepines and other hypnotics that correlate with the mechanisms of action and pharmacokinetics.
9. Opioid analgesics: agonists, partial agonists and antagonists - Describe the pharmacological (therapeutic and toxicological) characteristics and the methods of use of opioid analgesics: agonists, partial agonists and antagonists.
10. Principles of pain treatment.
11. Drugs used to treat migraine.
12. General anesthetics.
13. Drugs for Alzheimer's therapy.
14. Drugs in cerebral ischemia.
15. Experimental methods for the control of drug and xenobiotic toxicity.
16. Dose-effect and time-effect report of toxic diseases by drugs and xenobiotics.
17. Benzodiazepine dependence.
18. Acute alcoholism and alcohol use disorder.
19. Opioid use disorder.
20. Psychostimulants and hallucinogens, club-drugs.
21. CO and cyanide poisoning.
22. Pesticides.
23. Mushroom poisoning.
24. Antidotes and other anti-inflammatory measures.
25. Adverse drug reactions.
26. Drug allergy.
CLINICAL PHARMACOLOGY (IV YEAR – II SEMESTER)
1. Prescription drugs, controlled drug tables.
2. Pharmacovigilance.
3. Evidence-based medicine and clinical trials of drugs
4. Pharmacoepidemiology, pharmacoeconomics.
5. Complementary or alternative medicines, professional responsibilities, and appropriate behavior by the medical practitioner
6. Principles on which the effects of the major complementary or alternative therapies are based (Western phytotherapy, acupuncture, Chinese phytotherapy, ayurveda, homeopathy, osteopathy)
7. The role of phytotherapy in the light of scientific evidence and the main traditional branches of common use. Possible side effects and risks of drug interaction between phytotherapy and drug medication.