Kurt Faber, Biotransformations in Organic Chemistry, Springer Verlag 2011
Learning Objectives
Skills in identifying biocompatible methodologies as an alternative to classical organic synthesis for the obtainement of products with various applications (cosmetic, pharmacological, agrochemical, and so on).
Teaching Methods
Frontal lessons
Type of Assessment
Written test
Course program
Biotransformations: use and limits. Enzyme selectivity and models for its explanation. Enzyme classification. Hydrolases: mechanism and applications of esterases and lipases. Kinetic resolution. Meso trick. Reactions in non aqueous medium. Oxidoreductases: use of isolated enzymes and microorganisms. Vegetable systems. Use of multienzymatic systems for fragrances production. Aldolases. Modified biocatalysts: immobilised enzymes, conformational engineering. Active site modification. Artificial cells. Catalytic antibodies.