General concepts of glycoscience applied to modern medicine. Nomenclature and structure of the most representative glycans. Role of glycans in molecular recognition processes
Essential in glycobiology: https://www.ncbi.nlm.nih.gov/books/NBK310274/
Learning Objectives
A course on the molecular recognition mechanisms of membrane glycoconjugates involved in physio-pathological events is proposed.
Course program
1. Glycocalix: Glycolipids and glycoproteins structure and properties.
2. Symbolic representation of recurrent monosaccharide derivatives in membrane glycoconjugates.
3. Database for glycans and glycoconjugates.
4. Human lectins in molecular recognition (S-type, P-type and C-type).
5. The case of selections in molecular recognition.
6. Glycosyltransferase and glycosidase.
7. Fucosiltrasferase and are transferable.
8. Saccharide determinants involved in the rolling of leukocytes.
9. Determining saccharides and blood groups.
10. Cancer and selectins.
11. Saccharide antigens associated with tumours.
12. Bacterial and viral infections: the role of glycoconjugates in the early stages of infections.