Menù principale
B016923 - MEDICINAL CHEMISTRY
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Academic Year 2023-24
Course year
Third year - First Semester
Belonging Department
Experimantal and Clinical Medicine
Course Type
Single education field course
Scientific Area
CHIM/08 - PHARMACEUTICAL CHEMISTRY
Credits
6
Teaching Hours
48
Teaching Term
18/09/2023 ⇒ 22/12/2023
Attendance required
No
Type of Evaluation
Final Grade
Course Content
show
Course program
show
Lectureship
Teaching Language
Italian
Course Content
LEARNING AREA
Biotechnological disciplines with specific purposes: chemical and pharmaceutical
EDUCATIONAL OBJECTIVES
Knowledge and understanding:
Knowledge: basic notions of pharmaceutical chemistry.
Ability: understanding the mechanism of action of drugs.
Ability to apply knowledge and understanding:
Analysis of structure/activity correlations of drugs.
Biotechnological disciplines with specific purposes: chemical and pharmaceutical
EDUCATIONAL OBJECTIVES
Knowledge and understanding:
Knowledge: basic notions of pharmaceutical chemistry.
Ability: understanding the mechanism of action of drugs.
Ability to apply knowledge and understanding:
Analysis of structure/activity correlations of drugs.
Suggested readings (Search our library's catalogue)
Foye, Lemke, Williams. Principi di Chimica Farmaceutica (Piccin, Padova).
Patrick. Introduzione alla Chimica Farmaceutica (EdiSS, Napoli).
Patrick. Introduzione alla Chimica Farmaceutica (EdiSS, Napoli).
Learning Objectives
Knowledge and understanding:
Knowledge: basic notions of pharmaceutical chemistry.
Ability: understanding the mechanism of action of drugs.
Ability to apply knowledge and understanding:
Analysis of structure/activity correlations of drugs.
Knowledge: basic notions of pharmaceutical chemistry.
Ability: understanding the mechanism of action of drugs.
Ability to apply knowledge and understanding:
Analysis of structure/activity correlations of drugs.
Prerequisites
To take the exam the student must have passed Organic Chemistry.
Teaching Methods
Frontal lessons.
Further information
Teaching material available on the Moodle e-learning platform.
Type of Assessment
Written exam. The student can take a single final exam or a written test at the end of both modules; in this case the final grade will be the average of the two ongoing tests.
Course program
Module 1: Pharmaceutical Chemistry
1) Introduction to medicinal chemistry.
2) Chemical-physical properties and biological activity.
3) Structural properties and biological activity.
4) Bonds involved in the action of drugs.
5) Notes on pharmacokinetics and metabolism.
6) Drug research and development.
Module 2: Biotechnological drugs (therapeutic proteins)
1) Introduction: definitions and classification.
2) Insulin and analogues.
3) Tissue plasminogen activator (tPA).
4) Enfuvirtide.
5) Therapeutic monoclonal antibodies: definitions and examples.
6) Biopharmaceuticals for the treatment of tumors.
7) Biopharmaceuticals for the treatment of immune-mediated inflammatory diseases (rheumatoid arthritis).
1) Introduction to medicinal chemistry.
2) Chemical-physical properties and biological activity.
3) Structural properties and biological activity.
4) Bonds involved in the action of drugs.
5) Notes on pharmacokinetics and metabolism.
6) Drug research and development.
Module 2: Biotechnological drugs (therapeutic proteins)
1) Introduction: definitions and classification.
2) Insulin and analogues.
3) Tissue plasminogen activator (tPA).
4) Enfuvirtide.
5) Therapeutic monoclonal antibodies: definitions and examples.
6) Biopharmaceuticals for the treatment of tumors.
7) Biopharmaceuticals for the treatment of immune-mediated inflammatory diseases (rheumatoid arthritis).